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SECTION ONE
Orientation, Materials, Methods |
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| Introduction ........................................................................................................................................... | 1 | ||
| Abstract ................................................................................................................................................. | 5 | ||
| Chap.1 | Executive Summary of This Book .................................................................................................... | 7 | |
| 2 | Pre-1960 and Post-1960 Uses of Medical Radiation, and Its Carcinogenic Action ............. | 27 | |
| 3 | PhysPops --- The Doses in Some Massive Studies of Dose-Response .................................. | 53 | |
| 4 | Mortality Rates --- The Responses in the Dose-Response Studies ........................................ | 77 | |
| 5 | Dose-Response, Linear Regression, and Some Other Key Concepts in Our Analyses .......... | 89 | |
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SECTION TWO Cancer Mortality: Evidence that Medical Radiation Became a Principal Cause by 1940 |
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| 6 | All-Cancers-Combined, Males: Relation with Medical Radiation ......................................... | 107 | |
| 7 | All-Cancers-Combined, Females: Relation with Medical Radiation ..................................... | 119 | |
| 8 | Breast Cancer, Females ....................................................................................................................... | 125 | |
| 9 | Digestive-System Cancers, Males ................................................................................................... | 131 | |
| 10 | Digestive-System Cancers, Females ................................................................................................ | 137 | |
| 11 | Urinary-System Cancers, Males ....................................................................................................... | 143 | |
| 12 | Urinary-System Cancers, Females ................................................................................................... | 149 | |
| 13 | Genital Cancers, Males ....................................................................................................................... | 155 | |
| 14 | Genital Cancers, Females ................................................................................................................... | 161 | |
| 15 | Buccal-Cavity & Pharynx Cancers, Males .................................................................................... | 169 | |
| 16 | Respiratory-System Cancers, Males ................................................................................................ | 175 | |
| 17 | Respiratory-System Cancers, Females ............................................................................................ | 181 | |
| 18 | "Difference" Cancers (All-minus-Respiratory), Males ............................................................... | 187 | |
| 19 | "Difference" Cancers (All-minus-Respiratory), Females ........................................................... | 193 | |
| 20 | All-Cancer-Except-Genital-Cancer ............................................................................................ | 199 | |
| 21 | All-Cancer Except (Genital + Respiratory) .................................................................................. | 205 | |
| 22 | Summarized Results of Chapters 6 - 21, and Discussion ............................................................ | 209 | |
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SECTION THREE NonCancer NonIHD Mortality: Inverse Dose-Response with Medical Radiation |
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| 23 | All Causes of Death Combined: Relation with Medical Radiation ......................................... | 223 | |
| 24 | All Causes of Death Except Cancer ................................................................................................ | 229 | |
| 25 | All Causes of Death Except (Cancer + Ischemic Heart Disease) ............................................... | 233 | |
| 26 | Appendicitis, Deaths .......................................................................................................................... | 238 | |
| 27 | CNS Vascular-Lesions (Strokes), Deaths ...................................................................................... | 241 | |
| 28 | Chronic Nephritis, Deaths ................................................................................................................. | 244 | |
| 29 | Diabetes Mellitus, Deaths ................................................................................................................. | 247 | |
| 30 | Hypertensive Disease, Deaths .......................................................................................................... | 250 | |
| 31 | Influenza and Pneumonia, Deaths .................................................................................................... | 253 | |
| 32 | Fatal Motor-Vehicle Accidents ....................................................................................................... | 256 | |
| 33 | Other Fatal Accidents ......................................................................................................................... | 259 | |
| 34 | Rheumatic Fever & Rheumatic Heart Disease ............................................................................... | 262 | |
| 35 | Syphilis and Sequelae, Deaths .......................................................................................................... | 265 | |
| 36 | Tuberculosis, Deaths ........................................................................................................................... | 267 | |
| 37 | Ulcer of Stomach and Duodenum, Deaths ...................................................................................... | 270 | |
| 38 | Summary on NonCancer NonIHD Results: Facts "Demanding" an Explanation ................... | 272 | |
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SECTION FOUR Ischemic Heart Disease: Evidence that Medical Radiation Became an Important Cause by 1950 |
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| 39 | Ischemic Heart Disease: Medical Radiation as a Cause .............................................................. | 275 | |
| 40 | IHD in Males: The Dose-Response between Medical Radiation and IHD ............................ | 279 | |
| 41 | IHD in Females: The Dose-Response between Medical Radiation and IHD ........................ | 289 | |
| 42 | Similarities in the IHD and Cancer Findings: Tumors in Both Diseases? ............................... | 295 | |
| 43 | Nature of Atherosclerotic Lesions Underlying IHD .................................................................... | 299 | |
| 44 | Some "Schools" of Thought on IHD Etiology and on IHD Acute Fatal Events ..................... | 305 | |
| 45 | Unified Model: Intersection of Lipoproteins & Dysfunctional Clones of SMCs ................... | 337 | |
| 46 | How the Unified Model Helps to Explain, or Relates to, Other Observations ....................... | 345 | |
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SECTION FIVE Cancer and IHD Mortality after 1940: Fractional Causation by Medical Radiation |
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| 47 | Evaluating Fractional Causation in the Post-1940 Decades: How We Start ......................... | 355 | |
| 48 | Cigarette Smoking: When, Who, How Much, and Especially Where ..................................... | 361 | |
| 49 | All-Cancers, Males, 1940-1988: Fractional Causation by Medical Radiation .................... | 375 | |
| 50 | All-Cancers, Females, 1940-1988: Fractional Causation by Medical Radiation ................ | 387 | |
| 51 | Respiratory-System Cancers, Males, 1940-1988 ....................................................................... | 393 | |
| 52 | Respiratory-System Cancers, Females, 1940-1988 ................................................................... | 405 | |
| 53 | Difference-Cancers, Males, 1940-1988 ....................................................................................... | 411 | |
| 54 | Difference-Cancers, Females, 1940-1988 ................................................................................... | 417 | |
| 55 | Breast-Cancers, Females, 1940-1990 ........................................................................................... | 423 | |
| 56 | All-Cancers-Except-Genital, Females, 1940-1980 ................................................................. | 429 | |
| 57 | Digestive-System Cancers, Males, 1940-1988 ........................................................................... | 435 | |
| 58 | Digestive-System Cancers, Females, 1940-1988 ........................................................................ | 441 | |
| 59 | Urinary-System Cancers, Males, 1940-1980 ............................................................................... | 447 | |
| 60 | Urinary-System Cancers, Females, 1940-1980 ........................................................................... | 455 | |
| 61 | Genital Cancers, Males, 1940-1990 ............................................................................................... | 461 | |
| 62 | Genital Cancers, Females, 1940-1980 ........................................................................................... | 467 | |
| 63 | Buccal-Pharynx Cancers, Males, 1940-1980 .............................................................................. | 469 | |
| 64 | Ischemic Heart Disease, Males, 1950-1993 .................................................................................. | 477 | |
| 65 | Ischemic Heart Disease, Females, 1950-1993 .............................................................................. | 483 | |
| 66 | Summarized Results, from Evidence Which Spans about a Half-Century .............................. | 489 | |
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SECTION SIX The Status of Hypotheses One and Two |
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| 67 | Our Findings: In Conflict with Existing Evidence? ..................................................................... | 495 | |
| 68 | Is There a Reasonable Non-Radiation Explanation for the Observations? ............................ | 507 | |
| 69 | Conclusion: Making Sense of Three Sets of Irrefutable Correlations ....................................... | 513 | |
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APPENDICES |
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| App A | Dose-Units and Dose-Levels of Ionizing Radiation ................................................................ | 517 | |
| App B | The Safe-Dose Fallacy: Summary of Three Remarkably Similar Reports ............................. | 521 | |
| App C | The Free-Radical Fallacy about Ionizing Radiation: A Demonstration ................................ | 530 | |
| App D | Radiation-Induced Genomic Instability: What It Is, and Why It Is Important ..................... | 533 | |
| App E | Some Pathways toward Understanding the Atherogenic Role of Lipoproteins .................... | 538 | |
| App F | Dietary Advice in Prevention and Management of Ischemic Heart Disease .......................... | 555 | |
| App G | Any Goodness in "Good Cholesterol" ? ........................................................................................ | 577 | |
| App H | "Small, Dense Lipoprotein Particles" Especially Atherogenic?: Basis for Strong Doubt .... | 586 | |
| App I | "Snapshot" Epidemiology: Why Lipid Levels Seemed Less Important at Older Ages ........ | 594 | |
| App J | Coronary Effects of Very High-Dose Medical Radiation ........................................................ | 599 | |
| App K | Mid-Century: Average Annual Per Capita Dose from Diagnostic Medical Xrays .............. | 609 | |
| App L | Radiation "Hormesis": How an Illusion Can Arise from "Perfectly Good Data" .................. | 617 | |
| App M | Fractional Causation, 1980-1993, after an Alternate Smoking Adjustment ......................... | 621 | |
| App N | PhysPop Omitted: Correlations between Canc. & IHD MortRates (Past, Present) ................ | 642 | |
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Reference List .......................................................................................................................................................... |
645 | ||
| Index and Glossary ................................................................................................................................................. | 677 | ||