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Radiation from Medical Procedures in the Pathogenesis of Cancer and Ischemic Heart Disease
Dose-Response Studies with Physicians per 100,000 Population


          SECTION ONE
          Orientation, Materials, Methods

       Introduction ...........................................................................................................................................               1
       Abstract ................................................................................................................................................. 5
Chap.1      Executive Summary of This Book .................................................................................................... 7
2      Pre-1960 and Post-1960 Uses of Medical Radiation, and Its Carcinogenic Action ............. 27
3      PhysPops --- The Doses in Some Massive Studies of Dose-Response .................................. 53
4      Mortality Rates --- The Responses in the Dose-Response Studies ........................................ 77
5      Dose-Response, Linear Regression, and Some Other Key Concepts in Our Analyses .......... 89


          SECTION TWO
          Cancer Mortality: Evidence that Medical Radiation Became a Principal Cause by 1940

6      All-Cancers-Combined, Males: Relation with Medical Radiation ......................................... 107
7      All-Cancers-Combined, Females: Relation with Medical Radiation ..................................... 119
8      Breast Cancer, Females ....................................................................................................................... 125
9      Digestive-System Cancers, Males ................................................................................................... 131
10      Digestive-System Cancers, Females ................................................................................................ 137
11      Urinary-System Cancers, Males ....................................................................................................... 143
12      Urinary-System Cancers, Females ................................................................................................... 149
13      Genital Cancers, Males ....................................................................................................................... 155
14      Genital Cancers, Females ................................................................................................................... 161
15      Buccal-Cavity & Pharynx Cancers, Males .................................................................................... 169
16      Respiratory-System Cancers, Males ................................................................................................ 175
17      Respiratory-System Cancers, Females ............................................................................................ 181
18      "Difference" Cancers (All-minus-Respiratory), Males ............................................................... 187
19      "Difference" Cancers (All-minus-Respiratory), Females ........................................................... 193
20      All-Cancer-Except-Genital-Cancer ............................................................................................ 199
21      All-Cancer Except (Genital + Respiratory) .................................................................................. 205
22      Summarized Results of Chapters 6 - 21, and Discussion ............................................................ 209


          SECTION THREE
          NonCancer NonIHD Mortality: Inverse Dose-Response with Medical Radiation

23      All Causes of Death Combined: Relation with Medical Radiation ......................................... 223
24      All Causes of Death Except Cancer ................................................................................................ 229
25      All Causes of Death Except (Cancer + Ischemic Heart Disease) ............................................... 233
26      Appendicitis, Deaths .......................................................................................................................... 238
27      CNS Vascular-Lesions (Strokes), Deaths ...................................................................................... 241
28      Chronic Nephritis, Deaths ................................................................................................................. 244
29      Diabetes Mellitus, Deaths ................................................................................................................. 247
30      Hypertensive Disease, Deaths .......................................................................................................... 250
31      Influenza and Pneumonia, Deaths .................................................................................................... 253
32      Fatal Motor-Vehicle Accidents ....................................................................................................... 256
33      Other Fatal Accidents ......................................................................................................................... 259
34      Rheumatic Fever & Rheumatic Heart Disease ............................................................................... 262
35      Syphilis and Sequelae, Deaths .......................................................................................................... 265
36      Tuberculosis, Deaths ........................................................................................................................... 267
37      Ulcer of Stomach and Duodenum, Deaths ...................................................................................... 270
38      Summary on NonCancer NonIHD Results: Facts "Demanding" an Explanation ................... 272


          SECTION FOUR
          Ischemic Heart Disease: Evidence that Medical Radiation Became an Important Cause by 1950

39      Ischemic Heart Disease: Medical Radiation as a Cause .............................................................. 275
40      IHD in Males: The Dose-Response between Medical Radiation and IHD ............................ 279
41      IHD in Females: The Dose-Response between Medical Radiation and IHD ........................ 289
42      Similarities in the IHD and Cancer Findings: Tumors in Both Diseases? ............................... 295
43      Nature of Atherosclerotic Lesions Underlying IHD .................................................................... 299
44      Some "Schools" of Thought on IHD Etiology and on IHD Acute Fatal Events ..................... 305
45      Unified Model: Intersection of Lipoproteins & Dysfunctional Clones of SMCs ................... 337
46      How the Unified Model Helps to Explain, or Relates to, Other Observations ....................... 345


          SECTION FIVE
          Cancer and IHD Mortality after 1940: Fractional Causation by Medical Radiation

47      Evaluating Fractional Causation in the Post-1940 Decades: How We Start ......................... 355
48      Cigarette Smoking: When, Who, How Much, and Especially Where ..................................... 361
49      All-Cancers, Males, 1940-1988: Fractional Causation by Medical Radiation .................... 375
50      All-Cancers, Females, 1940-1988: Fractional Causation by Medical Radiation ................ 387
51      Respiratory-System Cancers, Males, 1940-1988 ....................................................................... 393
52      Respiratory-System Cancers, Females, 1940-1988 ................................................................... 405
53      Difference-Cancers, Males, 1940-1988 ....................................................................................... 411
54      Difference-Cancers, Females, 1940-1988 ................................................................................... 417
55      Breast-Cancers, Females, 1940-1990 ........................................................................................... 423
56      All-Cancers-Except-Genital, Females, 1940-1980 ................................................................. 429
57      Digestive-System Cancers, Males, 1940-1988 ........................................................................... 435
58      Digestive-System Cancers, Females, 1940-1988 ........................................................................ 441
59      Urinary-System Cancers, Males, 1940-1980 ............................................................................... 447
60      Urinary-System Cancers, Females, 1940-1980 ........................................................................... 455
61      Genital Cancers, Males, 1940-1990 ............................................................................................... 461
62      Genital Cancers, Females, 1940-1980 ........................................................................................... 467
63      Buccal-Pharynx Cancers, Males, 1940-1980 .............................................................................. 469
64      Ischemic Heart Disease, Males, 1950-1993 .................................................................................. 477
65      Ischemic Heart Disease, Females, 1950-1993 .............................................................................. 483
66      Summarized Results, from Evidence Which Spans about a Half-Century .............................. 489


          SECTION SIX
          The Status of Hypotheses One and Two

67      Our Findings: In Conflict with Existing Evidence? ..................................................................... 495
68      Is There a Reasonable Non-Radiation Explanation for the Observations? ............................ 507
69      Conclusion: Making Sense of Three Sets of Irrefutable Correlations ....................................... 513


          APPENDICES

  App A     Dose-Units and Dose-Levels of Ionizing Radiation ................................................................          517
  App B   The Safe-Dose Fallacy: Summary of Three Remarkably Similar Reports ............................. 521
  App C   The Free-Radical Fallacy about Ionizing Radiation: A Demonstration ................................ 530
  App D   Radiation-Induced Genomic Instability: What It Is, and Why It Is Important ..................... 533
  App E   Some Pathways toward Understanding the Atherogenic Role of Lipoproteins .................... 538
  App F   Dietary Advice in Prevention and Management of Ischemic Heart Disease .......................... 555
  App G   Any Goodness in "Good Cholesterol" ? ........................................................................................ 577
  App H   "Small, Dense Lipoprotein Particles" Especially Atherogenic?: Basis for Strong Doubt .... 586
  App I   "Snapshot" Epidemiology: Why Lipid Levels Seemed Less Important at Older Ages ........ 594
  App J   Coronary Effects of Very High-Dose Medical Radiation ........................................................ 599
  App K   Mid-Century: Average Annual Per Capita Dose from Diagnostic Medical Xrays .............. 609
  App L   Radiation "Hormesis": How an Illusion Can Arise from "Perfectly Good Data" .................. 617
  App M   Fractional Causation, 1980-1993, after an Alternate Smoking Adjustment ......................... 621
  App N   PhysPop Omitted: Correlations between Canc. & IHD MortRates (Past, Present) ................ 642


Reference List ..........................................................................................................................................................
645
Index and Glossary ................................................................................................................................................. 677





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